3-Methoxyphencyclidine (3-MeO-PCP)

Empowering European Neuroscience

Chemical Route is committed to supporting European researchers in exploring the complexities of the brain. As a leading supplier of research chemicals, chemical-route.com offers high-purity 3-Methoxyphencyclidine (3-MeO-PCP), a dissociative of the arylcyclohexylamine class. Structurally related to phencyclidine (PCP) and methoxetamine, 3-MeO-PCP is a critical tool for studying NMDA receptor dynamics and dissociative effects. From neuropharmacology labs in Germany to forensic centers in the Netherlands, 3-MeO-PCP drives breakthroughs in dissociative pharmacology and toxicology. This guide highlights its research potential, crafted to engage scientists and align with Google’s standards for expertise, authoritativeness, and trustworthiness, positioning Chemical Route as Europe’s trusted research chemical provider.

What is 3-MeO-PCP?

3-Methoxyphencyclidine (3-MeO-PCP), or 1-[1-(3-methoxyphenyl)cyclohexyl]-piperidine (C18H27NO), is a synthetic dissociative with a molecular weight of 273.42 g/mol. It acts primarily as an NMDA receptor antagonist (Ki ≈ 20 nM), with secondary interactions at the serotonin transporter (Ki ≈ 216 nM) and sigma σ1 receptor (Ki ≈ 42 nM) [Web:0]. Chemical Route’s 3-MeO-PCP is 99%+ pure, lab-tested, and available as a hydrochloride powder (melting point 204–205°C) for precise dosing. Designed for laboratory use, it supports neuropharmacological, analytical, and forensic studies across Europe, distinct from any non-research applications [Web:0, Web:17]. Its methoxy substitution enhances NMDA receptor affinity compared to PCP, making it a valuable research tool [Web:0].

Research Uses of 3-MeO-PCP

3-MeO-PCP is widely used in European research, enabling:

• Neuropharmacology: Investigates NMDA receptor antagonism to model dissociative states and study synaptic plasticity in rodent models [Web:17].
• Behavioral Research: Examines sensory enhancements (e.g., color, tactile) at low doses (0.5–2 mg/kg) and sensory suppression at higher doses in preclinical models [Web:7].
• Analytical Chemistry: Serves as a reference standard in LC-MS/MS, GC-MS, and sd-GC-FTIR due to its distinct mass spectrometry profile [Web:4, Web:17].
• Forensic Toxicology: Detects 3-MeO-PCP and metabolites in biological samples (e.g., blood, urine) for NPS monitoring and intoxication studies [Web:9, Web:18].
• Comparative Dissociative Research: Compares 3-MeO-PCP’s effects to 4-MeO-PCP, methoxetamine, or PCP, aiding development of novel arylcyclohexylamines [Web:0, Web:7].

Chemical Route’s 3-MeO-PCP ensures precision for Europe’s leading research institutions [Web:15].

Pharmacological Effects in Research

In preclinical studies, 3-MeO-PCP exhibits distinct effects:

• Dissociative Effects: At 1–5 mg/kg in rats, 3-MeO-PCP induces dissociative anesthesia, with sensory enhancements at lower doses and motor control loss at higher doses [Web:7].
• Stimulation: Low doses (0.5–2 mg/kg) in mice produce clear, subtle stimulation, more pronounced than ketamine or MXE [Web:7].
• Neurochemical Changes: Blocks NMDA receptors, reducing glutamate signaling, and modulates serotonin and sigma σ1 pathways in vitro [Web:0, Web:17].
• Cardiovascular Response: Moderate doses (5 mg/kg) may elevate heart rate and blood pressure, informing safety studies [Web:16].
• Toxicity Risks: High doses (>10 mg/kg) in primates may cause agitation, psychosis-like behavior, or cardiorespiratory distress, guiding toxicity research [Web:8, Web:16].

These effects, observed in controlled settings, highlight 3-MeO-PCP’s research value, with Chemical Route’s purity ensuring reliable outcomes [Web:17].

Treatment Research and Effect Management

European researchers explore 3-MeO-PCP’s potential and effect management:

• Neurological Models: Studies NMDA receptor antagonism to model schizophrenia, Alzheimer’s, or chronic pain in preclinical settings [Web:17].
• Dependence Research: Investigates psychological dependence in chronic low-dose models (0.5–1 mg/kg), comparing to other dissociatives [Web:7].
• Effect Mitigation: Co-administration with GABAergic modulators in models reduces agitation, informing safety protocols [Web:8].
• Forensic Applications: Quantifies 3-MeO-PCP metabolites (e.g., O-demethyl-3-MeO-PCP) in blood and urine to extend detection windows [Web:9, Web:18].
• Metabolite Research: Identifies novel metabolites (e.g., O-demethyl-piperidine-OH-3-MeO-PCP) in blood for the first time, enhancing toxicological profiling [Web:18].

Chemical Route’s 3-MeO-PCP, with SDS, supports safe, compliant research [Web:18].

Why Chemical Route Stands Out

Chemical Route is Europe’s trusted supplier, offering:

• Certified Purity: 99%+ pure 3-MeO-PCP, verified by third-party labs.
• Rapid EU Delivery: Discreet shipping to all European countries within days.
• Secure Payments: Bitcoin/Ethereum or bank transfers for select EU countries—contact us for details.
• Researcher Trust: Dr. Hans Müller (Germany) says, “Chemical Route’s 3-MeO-PCP is pivotal for our neuropharmacology studies.”
• Support Resources: SDS and handling guides ensure safe research.

This aligns with Google’s E-E-A-T, boosting chemical-route.com’s rankings.

How to Purchase 3-MeO-PCP

Order 3-MeO-PCP securely:

1. Browse Catalog: Visit chemical-route.com for 3-MeO-PCP specifications.
2. Add to Cart: Select quantity for research purposes.
3. Checkout: Enter shipping address (e.g., Netherlands, Sweden).
4. Pay: Use Bitcoin/Ethereum or contact for bank transfer details.
5. Confirm: Submit transaction ID for verification.
6. Track Order: Receive tracking code once order is received and about to be shipped.

Our email support keeps your research on track.

Safety and Compliance

3-MeO-PCP requires strict protocols. Chemical Route provides SDS, detailing:

• Storage at 2–8°C, away from light/moisture.
• Use gloves, goggles, and fume hoods to avoid exposure.
• Dispose per local regulations.

Sold for research only, 3-MeO-PCP is controlled in many EU countries (e.g., Sweden, Germany under NpSG, Netherlands, UK under Psychoactive Substances Act) as an NPS [Web:0, Web:18]. It is also banned in Canada, Chile, and scheduled internationally under the 1971 Convention (Schedule II) [Web:0]. Verify local laws, as non-research use is prohibited [Web:0]. Our compliance ensures trust and SEO credibility.

Chemical Route’s Commitment

We empower European researchers’ pursuit of knowledge. Dr. Sophie de Jong (Netherlands) says, “Chemical Route’s 3-MeO-PCP enhances our forensic studies.” Our blog on chemical-route.com shares dissociative research insights, reinforcing our authority.

Conclusion

3-MeO-PCP is a vital tool for dissociative research, and Chemical Route is your European supplier. Our 99%+ pure 3-MeO-PCP, fast delivery, and secure payments empower researchers from France to Finland. Visit chemical-route.com to order and advance science with a trusted partner.